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La maggior parte dei pazienti in cui sono stati riportati questi eventi presentava fattori di rischio cardiovascolare preesistenti. Tuttavia, non è possibile determinare in maniera definitiva se tali eventi siano direttamente correlati a questi fattori di rischio, a tadalafil, all’attività sessuale o alla combinazione di questi od altri fattori.
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Un induttore del CYP3A4, arrive la rifampicina, ha ridotto del ninety% la distribuzione del tadalafil, con possibile riduzione della sua efficacia. Altri induttori del CYP3A4, appear fenobarbital, fenitoina e carbamazepina potrebbero ridurre le concentrazioni plasmatiche di tadalafil.
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